The origin of CDK regulation

Li, Anatoliy and Blow, J. Julian (2001) The origin of CDK regulation. Nature Cell Biology, 3 (8). E182-E184. ISSN 1465-7392

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Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.

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Depositing User: LivePure Connector
Date Deposited: 10 Jun 2024 16:30
Last Modified: 10 Jun 2024 16:30
DOI: 10.1038/35087119

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