The origin of CDK regulation

Li, Anatoliy and Blow, J. Julian ORCID: https://orcid.org/0000-0002-9524-5849 (2001) The origin of CDK regulation. Nature Cell Biology, 3 (8). E182-E184. ISSN 1465-7392

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Abstract

Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.

Item Type:	Article
Faculty \ School:
Depositing User:	LivePure Connector
Date Deposited:	10 Jun 2024 16:30
Last Modified:	23 Jul 2024 02:24
URI:	https://ueaeprints.uea.ac.uk/id/eprint/95522
DOI:	10.1038/35087119

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