Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

Gillespie, Peter J., Li, Anatoliy and Blow, J. Julian (2001) Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BMC Biochemistry, 2. ISSN 1471-2091

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Abstract

In order to ensure precise chromosome duplication, eukaryotes "license" their replication origins during late mitosis and early G1 by assembling complexes of Mcm2-7 onto them. Mcm2-7 are essential for DNA replication, but are displaced from origins as they initiate, thus ensuring that no origin fires more than once in a single cell cycle.

Item Type: Article
Faculty \ School:
Depositing User: LivePure Connector
Date Deposited: 10 Jun 2024 16:30
Last Modified: 10 Jun 2024 16:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/95513
DOI: 10.1186/1471-2091-2-15

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