Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

Gillespie, Peter J., Li, Anatoliy and Blow, J. Julian ORCID: https://orcid.org/0000-0002-9524-5849 (2001) Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BMC Biochemistry, 2. ISSN 1471-2091

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Abstract

In order to ensure precise chromosome duplication, eukaryotes "license" their replication origins during late mitosis and early G1 by assembling complexes of Mcm2-7 onto them. Mcm2-7 are essential for DNA replication, but are displaced from origins as they initiate, thus ensuring that no origin fires more than once in a single cell cycle.

Item Type:	Article
Faculty \ School:
Depositing User:	LivePure Connector
Date Deposited:	10 Jun 2024 16:30
Last Modified:	18 Jun 2026 20:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/95513
DOI:	10.1186/1471-2091-2-15

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