The contribution of dormant origins to genome stability: from cell biology to human genetics

Alver, Robert C., Chadha, Gaganmeet Singh and Blow, J. Julian (2014) The contribution of dormant origins to genome stability: from cell biology to human genetics. DNA Repair, 19. pp. 182-189. ISSN 1568-7864

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Abstract

The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins.

Item Type: Article
Faculty \ School:
Depositing User: LivePure Connector
Date Deposited: 10 Jun 2024 15:30
Last Modified: 10 Jun 2024 15:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/95463
DOI: 10.1016/j.dnarep.2014.03.012

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