3 tera-basepairs as a fundamental limit for robust DNA replication

Al Mamun, M., Albergante, L., Blow, J. J. and Newman, T. J. (2020) 3 tera-basepairs as a fundamental limit for robust DNA replication. Physical Biology, 17 (4). ISSN 1478-3967

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In order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly and coherently. By studying the extreme limits of suppressing DNA replication failure due to double fork stall errors, we uncover a fundamental constant that describes a trade-off between genome size and architectural complexity of the developing organism. This constant has the approximate value N U ≈ 3 × 1012 basepairs, and depends only on two highly conserved molecular properties of DNA biology. We show that our theory is successful in interpreting a diverse range of data across the Eukaryota.

Item Type: Article
Additional Information: Funding information: MAM, LA and TJN acknowledge prior support from the Scottish Universities Life Sciences Alliance. JJB acknowledges support from Cancer Research UK (grant C303/A14301) and the Wellcome Trust (grant WT096598MA). TJN acknowledges prior support from the National Institutes of Health (Physical Sciences in Oncology Centers, U54 CA143682).
Uncontrolled Keywords: dna replication,double fork stalls,embryo development,eutely,polyploidy,robustness,theoretical analysis,molecular biology,biophysics,structural biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1312
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Depositing User: LivePure Connector
Date Deposited: 10 Jun 2024 10:31
Last Modified: 17 Jun 2024 08:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/95428
DOI: 10.1088/1478-3975/ab8c2f

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