The use of microphysiological systems to model metastatic cancer

Jackson, Caitlin E., Green, Nicola H., English, William R. ORCID: and Claeyssens, Frederik (2024) The use of microphysiological systems to model metastatic cancer. Biofabrication, 16 (3). ISSN 1758-5082

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Cancer is one of the leading causes of death in the 21st century, with metastasis of cancer attributing to 90% of cancer-related deaths. Therefore, to improve patient outcomes there is a need for better preclinical models to increase the success of translating oncological therapies into the clinic. Current traditional static in vitro models lack a perfusable network which is critical to overcome the diffusional mass transfer limit to provide a mechanism for the exchange of essential nutrients and waste removal, and increase their physiological relevance. Furthermore, these models typically lack cellular heterogeneity and key components of the immune system and tumour microenvironment. This review explores rapidly developing strategies utilising perfusable microphysiological systems (MPS) for investigating cancer cell metastasis. In this review we initially outline the mechanisms of cancer metastasis, highlighting key steps and identifying the current gaps in our understanding of the metastatic cascade, exploring MPS focused on investigating the individual steps of the metastatic cascade before detailing the latest MPS which can investigate multiple components of the cascade. This review then focuses on the factors which can affect the performance of an MPS designed for cancer applications with a final discussion summarising the challenges and future directions for the use of MPS for cancer models.

Item Type: Article
Additional Information: Funding Information: C J would like to thank the EPSRC, centre for doctoral training in Advanced Biomedical Materials for PhD studentship funding (EP/S022201/1). F C also thanks the Royal Society for funding of a Royal Society Leverhulme Trust Senior Research Fellowship 2022 (SRF\\R1\\221053). Funding Information: This research was funded by EPSRC, Grant Number: EP/S022201/1 and the Royal Society, Grant Number: SRF\\R1\\221053. Publisher Copyright: © 2024 The Author(s). Published by IOP Publishing Ltd.
Uncontrolled Keywords: cancer,lab-on-a-chip,metastasis,micro physiological systems,microfluidic,biotechnology,bioengineering,biochemistry,biomaterials,biomedical engineering,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1305
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 03 Jun 2024 11:30
Last Modified: 03 Jun 2024 11:31
DOI: 10.1088/1758-5090/ad3b70


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