Engineering of bespoke photosensitiser-microbe interfaces for enhanced semi-artificial photosynthesis

Jeuken, Lars J. C., Bishara Robertson, Imogen L., Zhang, Huijie, Reisner, Erwin and Butt, Julea N. ORCID: https://orcid.org/0000-0002-9624-5226 (2024) Engineering of bespoke photosensitiser-microbe interfaces for enhanced semi-artificial photosynthesis. Chemical Science. ISSN 2041-6520

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Abstract

Biohybrid systems for solar fuel production integrate artificial light-harvesting materials with biological catalysts such as microbes. In this perspective, we discuss the rational design of the abiotic-biotic interface in biohybrid systems by reviewing microbes and synthetic light-harvesting materials, as well as presenting various approaches to coupling these two components together. To maximise performance and scalability of such semi-artificial systems, we emphasise that the interfacial design requires consideration of two important aspects: attachment and electron transfer. It is our perspective that rational design of this photosensitiser-microbe interface is required for scalable solar fuel production. The design and assembly of a biohybrid with a well-defined electron transfer pathway allows mechanistic characterisation and optimisation for maximum efficiency. Introduction of additional catalysts to the system can close the redox cycle, omitting the need for sacrificial electron donors. Studies that electronically couple light-harvesters to well-defined biological entities, such as emerging photosensitiser-enzyme hybrids, provide valuable knowledge for the strategic design of whole-cell biohybrids. Exploring the interactions between light-harvesters and redox proteins can guide coupling strategies when translated into larger, more complex microbial systems.

Item Type: Article
Additional Information: Funding Information: The authors acknowledge the UK Biotechnology and Biological Sciences Research Council for funding (No. BB/S002499/1, BB/S00159X/1, and BB/S000704/1). ER acknowledges a UKRI/ERC Advanced Grant (No. EP/X030563/1).
Faculty \ School: Faculty of Science > School of Chemistry
Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Centre for Photonics and Quantum Science
Faculty of Science > Research Groups > Molecular Microbiology
Faculty of Science > Research Groups > Energy Materials Laboratory
Faculty of Science > Research Groups > Chemistry of Light and Energy
Faculty of Science > Research Groups > Chemistry of Life Processes
Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
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Depositing User: LivePure Connector
Date Deposited: 22 May 2024 09:31
Last Modified: 14 Jun 2024 13:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/95276
DOI: 10.1039/D4SC00864B

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