Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microbes

Wang, Jinyan, Curson, Andrew, Zhou, Shun, Carrion Fonseca, Ornella, Liu, Ji, Vieira, Ana, Walsham, Keanu, Monaco, Serena, Li, Chun-Yang, Dong, Qing-Yu, Wang, Yu, Rivera, Peter, Wang, Xiao-Di, Zhang, Min, Hanwell, Libby, Wallace, Matthew ORCID:, Zhu, Xiaoyu, Leao, Pedro, Lea-Smith, David ORCID:, Zhang, Yu-Zhong, Zhang, Xiao-Hua and Todd, Jonathan (2024) Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microbes. Nature Microbiology. ISSN 2058-5276 (In Press)

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Dimethylsulfoniopropionate (DMSP) is an abundant marine organosulfur compound with roles in stress protection, chemotaxis, nutrient and sulfur cycling and climate regulation. Here, we report the discovery of a bifunctional DMSP biosynthesis enzyme, DsyGD, in the transamination pathway of the rhizobacterium Gynuella sunshinyii and some filamentous cyanobacteria not previously known to produce DMSP. DsyGD produces DMSP through its N-terminal DsyG methylthiohydroxybutyrate (MTHB) S-methyltransferase and C-terminal DsyD dimethylsulfoniohydroxybutyrate (DMSHB) decarboxylase domains. Phylogenetically distinct DsyG-like proteins, termed DSYE, with MTHB S-methyltransferase (MSM) activity were found in diverse and environmentally abundant algae, comprising a mix of low, high and previously unknown DMSP producers. Algae containing DSYE, particularly bloom-forming Pelagophyceae species, were globally more abundant DMSP producers than those with previously described DMSP synthesis genes. This work greatly increases the number and diversity of predicted DMSP-producing organisms and highlights the importance of Pelagophyceae and other DSYE-containing algae in global DMSP production and sulfur cycling.

Item Type: Article
Uncontrolled Keywords: sdg 13 - climate action,sdg 14 - life below water ,/dk/atira/pure/sustainabledevelopmentgoals/climate_action
Faculty \ School: Faculty of Science > School of Biological Sciences
University of East Anglia Research Groups/Centres > Theme - ClimateUEA
Faculty of Science
Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Molecular Microbiology
Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User: LivePure Connector
Date Deposited: 26 Apr 2024 14:31
Last Modified: 29 Apr 2024 12:30

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