A one health perspective on Salmonella enterica serovar Infantis, an emerging human multidrug-resistant pathogen

Mattock, Jennifer, Chattaway, Marie Anne, Hartman, Hassan, Dallman, Timothy J., Smith, Anthony M., Keddy, Karen, Petrovska, Liljana, Manners, Emma J., Duze, Sanelisiwe T., Smouse, Shannon, Tau, Nomsa, Timme, Ruth, Baker, Dave J., Mather, Alison E., Wain, John and Langridge, Gemma C. (2024) A one health perspective on Salmonella enterica serovar Infantis, an emerging human multidrug-resistant pathogen. Emerging Infectious Diseases, 30 (4). pp. 701-710. ISSN 1080-6040

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Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.

Item Type: Article
Additional Information: Acknowledgements: Anaïs Painset for help with bioinformatics training. Heather Carleton for sharing isolate metadata with us. All clinical Salmonella isolates in South Africa are collected as part of activities in the NICD GERMS-SA Laboratory Surveillance Network. All participants involved in the GERMS-SA Network. Data availability: The Illumina FASTQ accessions for all the isolates are available in Appendix 2 Table 1. The ARIBA ResFinder, Plasmidfinder and gyrase results are in Appendix 2 Tables 2-4. The eBG31 reference genome can be accessed in GenBank (accession no. CP070301). Funding Information: J.M. was funded by the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Gastrointestinal Infections at University of Liverpool in partnership with Public Health England (PHE, now UKHSA), in collaboration with the University of East Anglia, University of Oxford and the Quadram Institute. E.M. was funded by the University of East Anglia. The project was part funded through the UKMRC Strategic Innovation Health Partnerships-Collaboration Research Project UK-South Africa. PI Karen Keddy. M.A.C. was supported in this study and received funding from the National Institute for Health Research (NIHR) Health Protection Research Unit in Genomics and Enabling Data (NIHR200892). The views expressed are those of the author(s) and not necessarily those of the NIHR, the Department of Health and Social Care or UKHSA. A.E.M., J.W. and G.C.L. were supported by the Biotechnology and Biological Sciences Research Council (BBSRC) Institute Strategic Programme Microbes in the Food Chain BB/R012504/1 and its constituent project BBS/E/F/000PR10348 (Theme 1, Epidemiology and Evolution of Pathogens in the Food Chain).
Uncontrolled Keywords: epidemiology,microbiology (medical),infectious diseases,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2713
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 19 Apr 2024 10:30
Last Modified: 06 Jun 2024 15:27
URI: https://ueaeprints.uea.ac.uk/id/eprint/94970
DOI: 10.3201/eid3004.231031


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