Fabrication of personalised medicines using additive printing technologies

Tam, Chak (2024) Fabrication of personalised medicines using additive printing technologies. Doctoral thesis, University of East Anglia.

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Personalised medicines, tailored to the specific needs of each patient, have emerged as a potential solution for improving therapeutic outcomes. This thesis explores two additive printing technologies using model drugs and polymers stated blow to fabricate drug delivery systems with the potential of personalisation. Additionally, characterisation of the printing parameters of each printing system was performed to understand their influence on the printing volume.

The microdispensing technology was used to fabricate personalised orodispersible films by on-demand printing of viscous ink containing paracetamol-hydroxypropyl methylcellulose onto a releasing substrate. Orodispersible films with personalised dosage were fabricated by changing the printing areas, which showed a linear relationship with the drug loading. The tensile strength of the printed film was comparable to that of the cast film and showed good handling propertied compared to the marketed product.

The nanoelectrospray (nES) technology was another printing method explored, which enables on-demand and layer-by-layer coating to deposit drug-loaded coatings on contact lenses. Zein, the model polymer, was used to characterise the spraying parameters of the custom-build nES system. This work showed that the contact lenses maintained an excellent vision zone after the nES coating process, and the spray volume was predictable using established scaling laws.

Polylactic-co-glycolic acid and three model drugs, ketotifen fumarate, bimatoprost and latanoprost, were coated in the peripheral region on commercially available contact lenses to assess the in vitro drug release and the influence of steam sterilisation to the coating. The drug loading of ketotifen fumarate and bimatoprost, was independent of in vitro drug release. Steam sterilisation was used to sterile the nES-coated contact lenses, and results showed that the method significantly damaged the drug-polymer coating. Gamma rays could be used as an alternative to minimize the damage to the drug-polymer coating.

Item Type: Thesis (Doctoral)
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Nicola Veasy
Date Deposited: 11 Apr 2024 15:33
Last Modified: 11 Apr 2024 15:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/94894


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