Cancer invasion and anaerobic bacteria: New insights into mechanisms

Hurst, Rachel, Brewer, Daniel S. ORCID:, Gihawi, Abraham ORCID:, Wain, John and Cooper, Colin S. ORCID: (2024) Cancer invasion and anaerobic bacteria: New insights into mechanisms. Journal of Medical Microbiology, 73 (3). ISSN 0022-2615

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There is growing evidence that altered microbiota abundance of a range of specific anaerobic bacteria are associated with cancer, including Peptoniphilus spp., Porphyromonas spp., Fusobacterium spp., Fenollaria spp., Prevotella spp., Sneathia spp., Veillonella spp., and Anaerococcus spp. linked to multiple cancer types. In this review we explore these pathogenic associations. The mechanisms by which bacteria are known or predicted to interact with human cells are reviewed and we present an overview of the interlinked mechanisms and hypotheses of how multiple intracellular anaerobic bacterial pathogens may act together to cause host cell and tissue microenvironment changes associated with carcinogenesis and cancer cell invasion. These include combined effects on changes in cell signalling, DNA damage, cellular metabolism and immune evasion. Strategies for early detection and eradication of anaerobic cancer associated bacterial pathogens that may prevent cancer progression are proposed.

Item Type: Article
Additional Information: Funding Information: This work was funded by the Bob Champion Cancer Trust, Prostate Cancer UK (RIA15-ST2-029), and the Alan Boswell Group Cancer Research Fellowship Funding.
Uncontrolled Keywords: anaerobic bacteria, polymicrobial, pathogenic, cancer, mechanisms, bacterial invasion, intracellular bacteria, aggressive cancer, metastases, infection,intracellular bacteria,metastases,infection,pathogenic,anaerobic bacteria,aggressive cancer,cancer,bacterial invasion,mechanisms,polymicrobial,microbiology (medical),microbiology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2726
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 08 Apr 2024 15:31
Last Modified: 15 Apr 2024 08:30
DOI: 10.1099/jmm.0.001817


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