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Alshammari, Muteb H., Alhunayhin, Sultanah M. N., Hughes, David L., Chambrier, Isabelle and Cammidge, Andrew N. 
ORCID: https://orcid.org/0000-0001-7912-4310
(2024)
Scramble-free synthesis of unhindered trans-A2B2-mesoaryl porphyrins via bromophenyl dipyrromethanes.
Organic Letters, 26 (8).
pp. 1561-1565.
ISSN 1523-7060
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Abstract
Trans-disubstituted porphyrins are highly valuable intermediates across diverse fields, but they pose a significant synthesis challenge in some cases due to scrambling and formation of complex mixtures. Conditions that minimize scrambling also lower yields, but steric hindrance around the meso-aryl substituent can effectively suppress scrambling altogether. Here we report a straightforward approach to valuable trans-A2B2 porphyrin intermediates that are otherwise very difficult to obtain, through use of removable blocking bromide substituents.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Chemistry Faculty of Science > School of Biological Sciences |
| Depositing User: | LivePure Connector |
| Date Deposited: | 08 Apr 2024 09:30 |
| Last Modified: | 09 Apr 2024 10:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/94851 |
| DOI: | 10.1021/acs.orglett.3c04215 |
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