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Allison, Matthew, Caramés-Méndez, Pablo, Hofmann, Benjamin J. 
ORCID: https://orcid.org/0000-0001-6408-3472, Pask, Christopher M., Phillips, Roger M., Lord, Rianne M. ORCID: https://orcid.org/0000-0001-9981-129X and McGowan, Patrick C.
(2023)
Cytotoxicity of ruthenium(II) arene complexes containing functionalized ferrocenyl β-diketonate ligands.
Organometallics, 42 (15).
pp. 1869-1881.
ISSN 0276-7333
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Abstract
The synthesis and characterization of 24 ruthenium(II) arene complexes of the type [(p-cym)RuCl(Fc-acac)] (where p-cym = p-cymene and Fc-acac = functionalized ferrocenyl β-diketonate ligands) are reported, including single-crystal X-ray diffraction for 21 new complexes. Chemosensitivity studies have been conducted against human pancreatic carcinoma (MIA PaCa-2), human colorectal adenocarcinoma p53-wildtype (HCT116 p53+/+) and normal human retinal epithelial cell lines (APRE-19). The most active complex, which contains a 2-furan-substituted ligand (4), is 5x more cytotoxic than the analogs 3-furan complex (5) against MIA PaCa-2. Several complexes were screened under hypoxic conditions and at shorter-time incubations, and their ability to damage DNA was determined by the comet assay. Compounds were also screened for their potential to inhibit the growth of both bacterial and fungal strains.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Chemistry |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 12 Mar 2024 13:30 |
| Last Modified: | 18 Mar 2024 09:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/94653 |
| DOI: | 10.1021/acs.organomet.2c00553 |
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