Influence of vitamin D supplementation on growth, body composition, pubertal development and spirometry in South African schoolchildren: A randomised controlled trial (ViDiKids)

Middelkoop, Keren, Micklesfield, Lisa, Stewart, Justine, Walker, Neil, Jolliffe, David A., Mendham, Amy E., Coussens, Anna K., Nuttall, James, Tang, Jonathan ORCID: https://orcid.org/0000-0001-6305-6333, Fraser, William D., Momand, Waheedullah, Cooper, Cyrus, Harvey, Nicholas C., Wilkinson, Robert J., Bekker, Linda-Gail and Martineau, Adrian R. (2024) Influence of vitamin D supplementation on growth, body composition, pubertal development and spirometry in South African schoolchildren: A randomised controlled trial (ViDiKids). BMJ Paediatrics Open, 8 (1). ISSN 2399-9772

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Abstract

Objective: To determine whether weekly oral vitamin D supplementation influences growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren. Design: Phase 3 double-blind randomised placebo-controlled trial (clinicaltrials.gov registration no. NCT02880982). Setting: Socio-economically disadvantaged peri-urban district of Cape Town, South Africa. Participants: 1682 children of Black African ancestry attending government primary schools and aged 6-11 years at baseline. Interventions: Oral vitamin D3 (10,000 IU/week) vs. placebo for 3 years. Main outcome measures: height-for-age and body mass index-for-age, measured in all participants); Tanner scores for pubertal development, spirometric lung volumes and body composition, measured in a subset of 450 children who additionally took part in a nested sub-study. Results: Mean serum 25-hydroxyvitamin D3 concentration at 3-year follow-up was higher among children randomised to receive vitamin D vs. placebo (104.3 vs. 64.7 nmol/L, respectively; mean difference [MD] 39.7 nmol/L, 95% CI 37.6 to 41.9 nmol/L). No statistically significant differences in height-for-age z-score (adjusted MD [aMD] -0.08, 95% CI -0.19 to 0.03) or body mass index-for-age z-score (aMD -0.04, 95% CI -0.16 to 0.07) were seen between vitamin D vs. placebo groups at follow-up. Among sub-study participants, allocation to vitamin D vs. placebo did not influence pubertal development scores, % predicted forced expiratory volume in 1 second (FEV1), % predicted forced vital capacity (FVC), % predicted FEV1/FVC, fat mass or fat-free mass. Conclusions: Weekly oral administration of 10,000 IU vitamin D3 boosted vitamin D status but did not influence growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren.

Item Type: Article
Additional Information: Funding information: This research was funded by the UK Medical Research Council (refs MR/R023050/1 and MR/M026639/1, both awarded to AM). RJW is supported by The Francis Crick Institute which receives funding from Wellcome (CC2112), Cancer Research UK (CC2112) and UK Research and Innovation (Medical Research Council CC2112). He also receives support from Wellcome (203135) and in part by the NIHR Biomedical Research Centre of Imperial College NHS Trust.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User: LivePure Connector
Date Deposited: 05 Mar 2024 09:32
Last Modified: 12 Apr 2024 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/94571
DOI: 10.1136/bmjpo-2024-002495

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