Sialic acids in infection and their potential use in detection and protection against pathogens

Dedola, Simone, Ahmadipour, Sanaz, de Andrade, Peterson, Baker, Alexander N., Boshra, Andrew N., Chessa, Simona, Gibson, Matthew I., Hernando, Pedro J., Ivanova, Irina M., Lloyd, Jessica E., Marin, Maria J. ORCID:, Munro-Clark, Alexandra J., Pergolizzi, Giulia, Richards, Sarah-Jane, Ttofi, Iakovia, Wagstaff, Ben A. and Field, Robert A. (2024) Sialic acids in infection and their potential use in detection and protection against pathogens. RSC Chemical Biology, 5 (3). pp. 167-188. ISSN 2633-0679

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In structural terms, the sialic acids are a large family of nine carbon sugars based around an alpha-keto acid core. They are widely spread in nature, where they are often found to be involved in molecular recognition processes, including in development, immunology, health and disease. The prominence of sialic acids in infection is a result of their exposure at the non-reducing terminus of glycans in diverse glycolipids and glycoproteins. Herein, we survey representative aspects of sialic acid structure, recognition and exploitation in relation to infectious diseases, their diagnosis and prevention or treatment. Examples covered span influenza virus and Covid-19, Leishmania and Trypanosoma, algal viruses, Campylobacter, Streptococci and Helicobacter, and commensal Ruminococci.

Item Type: Article
Additional Information: Acknowledgements: This work was supported by the IUK Biomedical Internship (to S. A.), the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (grant agreement no. 866056 to M. I. G.). The University of Warwick, the EPSRC (EP/R511808/1), and BBSRC (BB/S506783/1) IAA accounts, (to M. I. G., S.-J. R. and A. N. B.); the Marie Skłodowska-Curie Actions (MSCA), as part of the Horizon 2020 programme funded by the EU Commission (grant agreement 814102 – Sweet Crosstalk to P. H.; and grant agreement 956758 – Glytunes, to I. T.); a scholarship from the Ministry of Higher Education of the Arab Republic of Egypt (ID: MM29/21, to A. B.); the University of Manchester (J. E. L., B. A. W., P. de A., A. M.-C., R. A. F.). The authors acknowledge the University of East Anglia and the Quadram Institute, Norwich as hosts for this project. Figures were created by using templates from the Library of Scientific & Medical illustration (licence CC BY-NC-SA 4.0) ( The 3D model in Fig. 19 is based on PDB structure 1HGG and was created by using UCSF Chimera, developed by the Resource for Biocomputing, Visualization and Informatics at the University of California, San Francisco, with support from NIH P41-GM103311.
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Centre for Photonics and Quantum Science
Faculty of Science > Research Groups > Chemistry of Life Processes
Faculty of Science > Research Groups > Chemistry of Light and Energy
Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
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Depositing User: LivePure Connector
Date Deposited: 09 Jan 2024 01:38
Last Modified: 08 Apr 2024 10:30
DOI: 10.1039/D3CB00155E


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