Sialic acids in infection and their potential use in detection and protection against pathogens

Dedola, Simone, Ahmadipour, Sanaz, de Andrade, Peterson, Baker, Alexander N., Boshra, Andrew N., Chessa, Simona, Gibson, Matthew I., Hernando, Pedro J., Ivanova, Irina M., Lloyd, Jessica E., Marin, Maria J. ORCID: https://orcid.org/0000-0001-8021-5498, Munro-Clark, Alexandra J., Pergolizzi, Giulia, Richards, Sarah-Jane, Ttofi, Iakovia, Wagstaff, Ben A. and Field, Robert A. (2024) Sialic acids in infection and their potential use in detection and protection against pathogens. RSC Chemical Biology. ISSN 2633-0679 (In Press)

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Abstract

In structural terms, the sialic acids are a large family of nine carbon sugars based around an alpha-keto acid core. They are widely spread in nature, where they are often found to be involved in molecular recognition processes, including in development, immunology, health and disease. The prominence of sialic acids in infection is a result of their exposure at the non-reducing terminus of glycans in diverse glycolipids and glycoproteins. Herein, we survey representative aspects of sialic acid structure, recognition and exploitation in relation to infectious diseases, their diagnosis and prevention or treatment. Examples covered span influenza virus and Covid-19, Leishmania and Trypanosoma, algal viruses, Campylobacter, Streptococci and Helicobacter, and commensal Ruminococci.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Centre for Photonics and Quantum Science
Faculty of Science > Research Groups > Chemistry of Life Processes
Faculty of Science > Research Groups > Chemistry of Light and Energy
Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Depositing User: LivePure Connector
Date Deposited: 09 Jan 2024 01:38
Last Modified: 09 Jan 2024 01:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/94113
DOI: 10.1039/D3CB00155E

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