Late-onset vitamin K deficiency bleeding in an extremely preterm infant fed an exclusively human milk–based diet

Vasu, Vimal, Mulla, Shaveta, Pandya, Atisha, Card, David, Shearer, Martin J. and Clarke, Paul ORCID: https://orcid.org/0000-0001-6203-7632 (2023) Late-onset vitamin K deficiency bleeding in an extremely preterm infant fed an exclusively human milk–based diet. Journal of Thrombosis and Haemostasis. ISSN 1538-7933

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Abstract

All newborns need extra phylloquinone (vitamin K1; K1) to prevent vitamin K deficiency bleeding (VKDB). In preterm babies, the main sources are prophylactic K1 given at birth and parenteral and/or enteral feeding thereafter. Preterm babies are at risk of late-onset VKDB if ongoing K1 supplementation is inadequate. For extremely preterm infants fed an exclusive human milk diet, the low K1 content of human milk may predispose them to vitamin K deficiency. Human milk fortification with either bovine milk–derived fortifier or human milk–based fortifier (HMF) made from pooled donor milk is a widely used strategy to improve the micronutrient and growth status of preterm infants. However, the K1 content of HMF is markedly lower than that of bovine-based preparations. We present an unusual case of late-onset VKDB in an extremely preterm infant who received an exclusive human milk diet and HMF and quantify total K1 intake prior to the bleeding.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 03 Jan 2024 03:18
Last Modified: 03 Jan 2024 03:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/94042
DOI: 10.1016/j.jtha.2023.10.029

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