Tools
Tools
Kourelis, Jiorgos 
ORCID: https://orcid.org/0000-0002-9007-1333 and van der Hoorn, Renier A. L.
(2018)
Defended to the nines: 25 years of resistance gene cloning identifies nine mechanisms for R protein function.
Plant Cell, 30 (2).
pp. 285-299.
ISSN 1040-4651
Preview |
PDF (plcell_v30_2_285)
- Published Version
Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Plants have many, highly variable resistance (R) gene loci, which provide resistance to a variety of pathogens. The first R gene to be cloned, maize (Zea mays) Hm1, was published over 25 years ago, and since then, many different R genes have been identified and isolated. The encoded proteins have provided clues to the diverse molecular mechanisms underlying immunity. Here, we present a meta-analysis of 314 cloned R genes. The majority of R genes encode cell surface or intracellular receptors, and we distinguish nine molecular mechanisms by which R proteins can elevate or trigger disease resistance: direct (1) or indirect (2) perception of pathogen-derived molecules on the cell surface by receptor-like proteins and receptor-like kinases; direct (3) or indirect (4) intracellular detection of pathogen-derived molecules by nucleotide binding, leucine-rich repeat receptors, or detection through integrated domains (5); perception of transcription activator-like effectors through activation of executor genes (6); and active (7), passive (8), or host reprogramming-mediated (9) loss of susceptibility. Although the molecular mechanisms underlying the functions of R genes are only understood for a small proportion of known R genes, a clearer understanding of mechanisms is emerging and will be crucial for rational engineering and deployment of novel R genes.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This work was supported by the European Research Council (616449), by the Clarendon Fund, and by the University of Oxford. |
| Uncontrolled Keywords: | plant science,cell biology ,/dk/atira/pure/subjectarea/asjc/1100/1110 |
| Faculty \ School: | Faculty of Science > The Sainsbury Laboratory |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 07 Dec 2023 01:45 |
| Last Modified: | 01 Feb 2024 03:07 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/93891 |
| DOI: | 10.1105/tpc.17.00579 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |