DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms

Carrion Fonseca, Ornella, Todd, Jonathan, Curson, Andrew, Walsham, Keanu, Zhu, Xiaoyu and Monaco, Serena (2023) DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms. Nature Microbiology. ISSN 2058-5276 (In Press)

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Abstract

Dimethylsulfoxonium propionate (DMSOP) is a recently identified and abundant marine organosulfur compound with roles in oxidative stress protection, global carbon and sulfur cycling and, as shown here, potentially in osmotolerance. Microbial DMSOP cleavage yields dimethyl sulfoxide (DMSO), a ubiquitous marine metabolite and acrylate, but the enzymes responsible and their environmental importance were unknown. Here, we report DMSOP cleavage mechanisms in diverse heterotrophic bacteria, fungi and phototrophic algae not previously known to have this activity, and highlight the unappreciated importance of this process in marine sediment environments. These diverse organisms, including Roseobacter and SAR11 bacteria and Emiliania huxleyi, utilised their dimethylsulfoniopropionate (DMSP) lyase ‘Ddd’ or ‘Alma’ enzymes to cleave DMSOP via similar catalytic mechanisms to those for DMSP. Given the predicted teragram DMSOP production budget and its prevalence in marine sediments, our results highlight that DMSOP cleavage is likely a globally significant process influencing carbon and sulfur fluxes and ecological interactions.

Item Type:	Article
Uncontrolled Keywords:	dimethylsulfoxonium propionate,dimethylsulfoniopropionate,dimethylsulfoxide,dimethylsulfide,dmsp lyases,marine sulfur cycle,sdg 14 - life below water ,/dk/atira/pure/sustainabledevelopmentgoals/life_below_water
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Molecular Microbiology
Depositing User:	LivePure Connector
Date Deposited:	10 Nov 2023 03:23
Last Modified:	13 Nov 2023 18:01
URI:	https://ueaeprints.uea.ac.uk/id/eprint/93617
DOI:	10.1038/s41564-023-01526-4

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