Increased beta adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion

Langdon, Peter E. ORCID: https://orcid.org/0000-0002-7745-1825, Harley, Carolyn W. and McLean, John H. (1997) Increased beta adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion. Developmental Brain Research, 102 (2). pp. 291-293. ISSN 0165-3806

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Abstract

It was hypothesized that 5-HT2 receptors in the olfactory bulb prime the bulbar response to a β adrenoceptor mediated unconditioned stimulus (UCS) during odor preference learning in 1-week-old rat pups. The ability of 4 mg/kg of isoproterenol+stroking and 6 mg/kg of isoproterenol+no stroking to induce normal odor preference learning in pups depleted of bulbar 5-HT in the present study supports the hypothesis. The inverted-U curve relation between UCS strength and learning also appears to occur within the bulb.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	LivePure Connector
Date Deposited:	12 Oct 2023 00:42
Last Modified:	12 Oct 2023 00:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/93264
DOI:	10.1016/S0165-3806(97)00090-4

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