Increased beta adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion

Langdon, Peter E., Harley, Carolyn W. and McLean, John H. (1997) Increased beta adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion. Developmental Brain Research, 102 (2). pp. 291-293. ISSN 0165-3806

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Abstract

It was hypothesized that 5-HT2 receptors in the olfactory bulb prime the bulbar response to a β adrenoceptor mediated unconditioned stimulus (UCS) during odor preference learning in 1-week-old rat pups. The ability of 4 mg/kg of isoproterenol+stroking and 6 mg/kg of isoproterenol+no stroking to induce normal odor preference learning in pups depleted of bulbar 5-HT in the present study supports the hypothesis. The inverted-U curve relation between UCS strength and learning also appears to occur within the bulb.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	LivePure Connector
Date Deposited:	12 Oct 2023 00:42
Last Modified:	06 Feb 2025 11:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/93264
DOI:	10.1016/S0165-3806(97)00090-4

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