Understanding the evolution of immune genes in jawed vertebrates

Vinkler, Michal, Fiddaman, Steven R., Těšický, Martin, O'Connor, Emily A., Savage, Anna E., Lenz, Tobias L., Smith, Adrian L., Kaufman, Jim, Bolnick, Daniel I., Davies, Charli S., Dedić, Neira, Flies, Andrew S., Gómez Samblás, M. Mercedes, Henschen, Amberleigh E., Novák, Karel, Palomar, Gemma, Raven, Nynke, Samaké, Kalifa, Slade, Joel, Veetil, Nithya Kuttiyarthu, Voukali, Eleni, Höglund, Jacob, Richardson, David S. ORCID: https://orcid.org/0000-0001-7226-9074 and Westerdahl, Helena (2023) Understanding the evolution of immune genes in jawed vertebrates. Journal of Evolutionary Biology, 36 (6). pp. 847-873. ISSN 1010-061X

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Driven by co-evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in genetics, genomics and transcriptomics have enabled a more detailed investigation into how immunogenetic variation shapes the diversity of immune responses seen across domestic and wild animal species. However, a deeper understanding of the diverse molecular mechanisms that shape immunity within and among species is still needed to gain insight into-and generate evolutionary hypotheses on-the ultimate drivers of immunological differences. Here, we discuss current advances in our understanding of molecular evolution underpinning jawed vertebrate immunity. First, we introduce the immunome concept, a framework for characterizing genes involved in immune defence from a comparative perspective, then we outline how immune genes of interest can be identified. Second, we focus on how different selection modes are observed acting across groups of immune genes and propose hypotheses to explain these differences. We then provide an overview of the approaches used so far to study the evolutionary heterogeneity of immune genes on macro and microevolutionary scales. Finally, we discuss some of the current evidence as to how specific pathogens affect the evolution of different groups of immune genes. This review results from the collective discussion on the current key challenges in evolutionary immunology conducted at the ESEB 2021 Online Satellite Symposium: Molecular evolution of the vertebrate immune system, from the lab to natural populations.

Item Type: Article
Additional Information: Research Funding: Biotechnology and Biological Sciences Research Council. Grant Numbers: BB/K004468/1, BB/M011224/1, BB/N023803/1, BB/V000756/1; Department for Environment, Food and Rural Affairs, UK Government. Grant Number: OD0221; Deutsche Forschungsgemeinschaft. Grant Number: 437857095; Grantová Agentura České Republiky. Grant Number: 19-20152Y; Grantová Agentura, Univerzita Karlova. Grant Number: 646119; H2020 European Research Council. Grant Number: ERC-2019-StG-853272-PALAEOFARM; John Fell Fund, University of Oxford. Grant Number: 0005172; Ministerstvo Školství, Mládeže a Tělovýchovy. Grant Number: SVV 260684/2023; Ministerstvo Zemědělství. Grant Number: MZE-RO0723 National Institutes of Health. Grant Number: 1R01AI123659-01A1; Univerzita Karlova v Praze. Grant Number: START/SCI/113 with reg. no. CZ.02.2.69/0.0/0.0/19_; Vetenskapsrådet. Grant Number: 2020-04285
Uncontrolled Keywords: mhc,adaptation,adaptive immunity,evolutionary immunology,genomics,host-parasite interactions,immunogenetics,innate immunity,molecular evolution,vertebrates,ecology, evolution, behavior and systematics ,/dk/atira/pure/subjectarea/asjc/1100/1105
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation
Faculty of Science > Research Groups > Organisms and the Environment
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Depositing User: LivePure Connector
Date Deposited: 15 Sep 2023 14:30
Last Modified: 25 Sep 2023 08:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/93051
DOI: 10.1111/jeb.14181

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