Effects of high dietary chicken protein on obesity development of rats fed high-fat diets

Song, Shangxin, Gao, Yulin, Xia, Tianlan, Zhou, Yefei, Hooiveld, Guido J. E. J., Muller, Michael ORCID: https://orcid.org/0000-0002-5930-9905 and Li, Chunbao (2023) Effects of high dietary chicken protein on obesity development of rats fed high-fat diets. Journal of Functional Foods, 108. ISSN 1756-4646

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Abstract

This study explored the effects of dietary chicken protein at high (HCK, 40 % E) or normal (CK, 20 % E) levels on obesity development of rats fed high-fat diets. Compared with the CK diet, the HCK diet reduced body weight gain (by 15 %), epididymal adipose tissue mass (by 18.4 %), and adipocyte size (by 18.8 %) significantly without affecting the food intake of rats. It also reduced blood insulin and glycosylated serum protein (GSP) significantly by 45.4 % and 14.3 %, respectively; however, the OGTT and HOMA-IR results were not different. The HCK diet downregulated EAT transcriptomics related to the biosynthesis of cholesterol, triglycerides, and fatty acids, which were highly correlated with the most downregulated hub genes, Insig1, Srebf2, Hmgcs1, and Fasn. Therefore, high dietary chicken protein content reduced body fat accumulation, blood insulin, and GSP, and downregulated EAT transcriptomics related to lipid biosynthesis in rats fed high-fat diets.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	LivePure Connector
Date Deposited:	08 Aug 2023 09:31
Last Modified:	14 Aug 2023 01:26
URI:	https://ueaeprints.uea.ac.uk/id/eprint/92810
DOI:	10.1016/j.jff.2023.105713

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