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Kadia, Benjamin Momo, Otiti, Mary Iwaret, Ramsteijn, Anouschka, Sow, Doudou, Faye, Babacar, Heffernan, Claire, Hall, Lindsay J 
ORCID: https://orcid.org/0000-0001-8938-5709, Webster, Joanne P., Walker, Alan W. and Allen, Stephen
(2023)
Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth.
Nutrition Reviews.
ISSN 0029-6643
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Abstract
In children exposed to poor hygiene and sanitation, invasion of the gut by pathogenic microbes can result in a subclinical enteropathy termed “environmental enteric dysfunction” (EED) that contributes to undernutrition, growth faltering, and impaired organ development. EED may already be present by age 6–12 weeks; therefore, interventions that can be started early in life, and used alongside breastfeeding, are needed to prevent or ameliorate EED. A healthy gut microbiota is critical for intestinal development and repair, nutrient digestion and absorption, and resisting colonization or overgrowth by pathogens. However, its development can be impaired by several environmental factors. Dietary supplementation with pro-, pre-, or synbiotics may be a pragmatic and safe means of building the resilience of the developing gut microbiota against adverse environmental factors, thereby preventing EED.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 2 - zero hunger ,/dk/atira/pure/sustainabledevelopmentgoals/zero_hunger |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Depositing User: | LivePure Connector |
| Date Deposited: | 01 Aug 2023 12:31 |
| Last Modified: | 07 Aug 2023 00:49 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/92754 |
| DOI: | 10.1093/nutrit/nuad050 |
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