The role of human milk fats in shaping neonatal development and the early life gut microbiota

Seki, David, Errerd, Theresa and Hall, Lindsay J. ORCID: (2023) The role of human milk fats in shaping neonatal development and the early life gut microbiota. Microbiome Research Reports, 2 (2). ISSN 2771-5965

[thumbnail of 5576]
PDF (5576) - Published Version
Available under License Creative Commons Attribution.

Download (387kB) | Preview


Human breast milk (HBM) is the main source of nutrition for neonates across the critical early-life developmental period. The highest demand for energy is due to rapid neurophysiological expansion post-delivery, which is largely met by human milk lipids (HMLs). These HMLs also play a prebiotic role and potentially promote the growth of certain commensal bacteria, which, via HML digestion, supports the additional transfer of energy to the infant. In tandem, HMLs can also exert bactericidal effects against a variety of opportunistic pathogens, which contributes to overall colonisation resistance. Such interactions are pivotal for sustaining homeostatic relationships between microorganisms and their hosts. However, the underlying molecular mechanisms governing these interactions remain poorly understood. This review will explore the current research landscape with respect to HMLs, including compositional considerations and impact on the early life gut microbiota. Recent papers in this field will also be discussed, including a final perspective on current knowledge gaps and potential next research steps for these important but understudied breast milk components.

Item Type: Article
Additional Information: Funding Information: Lindsay J. Hall is supported by Wellcome Trust Investigator Awards (100974/C/13/Z) and (220876/Z/20/Z); and a BBSRC Institute Strategic Programme, Gut Microbes and Health (BB/R012490/1), and its constituent projects (BBS/E/F/000PR10353) and (BBS/E/F/000PR10356).
Uncontrolled Keywords: early life,breast milk,fat,gut microbiota,lipids,metabolism,microbiology ,/dk/atira/pure/subjectarea/asjc/2400/2404
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 01 Aug 2023 11:31
Last Modified: 13 Jan 2024 01:35
DOI: 10.20517/mrr.2023.09


Downloads per month over past year

Actions (login required)

View Item View Item