Purging and accumulation of genetic load in conservation

Dussex, Nicolas, Morales, Hernán E., Grossen, Christine, Dalén, Love and van Oosterhout, Cock ORCID: https://orcid.org/0000-0002-5653-738X (2023) Purging and accumulation of genetic load in conservation. Trends in Ecology and Evolution, 38 (10). pp. 961-969. ISSN 0169-5347

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Our ability to assess the threat posed by the genetic load to small and declining populations has been greatly improved by advances in genome sequencing and computational approaches. Yet, considerable confusion remains around the definitions of the genetic load and its dynamics, and how they impact individual fitness and population viability. We illustrate how both selective purging and drift affect the distribution of deleterious mutations during population size decline and recovery. We show how this impacts the composition of the genetic load, and how this affects the extinction risk and recovery potential of populations. We propose a framework to examine load dynamics and advocate for the introduction of load estimates in the management of endangered populations.

Item Type: Article
Additional Information: Acknowledgments: The authors acknowledge funding from Carl Tryggers Foundation (Grant CTS 19: 257; to N.D.), the European Union’s Horizon 2020 research and innovation programme under a Marie Skłodowska-Curie grant (840519; to H.E.M), the Swiss National Science Foundation (grant 31003A_182343; to C.G.), and the Swedish Research Council (grant nr 2021-00625; to L.D.). The code used for simulations (Figure 3) has been deposited at: https://github.com/hmoral/purging.
Uncontrolled Keywords: bottleneck,conservation,genetic load,genomic erosion,purging,ecology, evolution, behavior and systematics ,/dk/atira/pure/subjectarea/asjc/1100/1105
Faculty \ School: Faculty of Science > School of Environmental Sciences
UEA Research Groups: Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 21 Jul 2023 13:30
Last Modified: 14 Sep 2023 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/92647
DOI: 10.1016/j.tree.2023.05.008


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