Acinetobacter baumannii from grass: novel but non-resistant clones

Mateo-Estrada, Valeria, Tyrrell, Ciara, Evans, Ben ORCID:, Aguilar-Vera, Alejandro, Drissner, David, Castillo-Ramirez, Santiago and Walsh, Fiona (2023) Acinetobacter baumannii from grass: novel but non-resistant clones. Microbial Genomics, 9 (7). ISSN 2057-5858

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Acinetobacter baumannii is one the most worrisome nosocomial pathogens, which has long been considered almost mainly as a hospital-associated bacterium. There have been some studies about animal and environmental isolates over the last decade. However, little effort has been made to determine if this pathogen dwells in the grass. Here, we aim to determine the evolutionary relationships and antibiotic resistance of clones of A. baumannii sampled from grass to the major human international clones and animal clones. Two hundred and forty genomes were considered in total from four different sources for this study. Our core and accessory genomic epidemiology analyses showed that grass isolates cluster in seven groups well differentiated from one another and from the major human and animal isolates. Furthermore, we found new sequence types under both multilocus sequence typing schemes: two under the Pasteur scheme and seven for the Oxford scheme. The grass isolates contained fewer antibiotic-resistance genes and were not resistant to the antibiotics tested. Our results demonstrate that these novel clones appear to have limited antibiotic resistance potential. Given our findings, we propose that genomic epidemiology and surveillance of A. baumannii should go beyond the hospital settings and consider the environment in an explicit One Health approach.

Item Type: Article
Additional Information: Funding information: This study was supported by the: CONACyT PhD fellowship (Award 1005234); CONACyT Ciencia Básica (Award 284276); Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica PAPIIT (Award IN206019); Walsh Fellowship (Award 2017037)
Uncontrolled Keywords: acinetobacter baumannii,genomic epidemiology,one health,antibiotic resistance,grass,international clones,non-clinical environments,epidemiology,microbiology,molecular biology,genetics ,/dk/atira/pure/subjectarea/asjc/2700/2713
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 14 Jul 2023 08:30
Last Modified: 19 Oct 2023 03:36
DOI: 10.1099/mgen.0.001054


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