Cut-off scores for mild and moderate dementia on the Addenbrooke's Cognitive Examination-III and the Mini-Addenbrooke's Cognitive Examination compared with the Mini-Mental State Examination

McCarthy, Louise, Rubinsztein, Judy, Lowry, Ellen, Flanagan, Emma, Menon, Vandana, Vearncombe, Silvia, Mioshi, Eneida and Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788 (2023) Cut-off scores for mild and moderate dementia on the Addenbrooke's Cognitive Examination-III and the Mini-Addenbrooke's Cognitive Examination compared with the Mini-Mental State Examination. BJPsych Bulletin. ISSN 2056-4694

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Abstract

Aims and method: We aimed to establish cut-off scores to stage dementia on the Addenbrooke's Cognitive Examination-III (ACE-III) and the Mini-Addenbrooke's Cognitive Examination (M-ACE) compared with scores traditionally used with the Mini-Mental State Examination (MMSE). Our cross-sectional study recruited 80 patients and carers from secondary care services in the UK. Results: A score ≤76 on the ACE-III and ≤19 on the M-ACE correlated well with MMSE cut-offs for mild dementia, with a good fit on the receiver operating characteristic analysis for both the ACE-III and M-ACE. The cut-off for moderate dementia had lower sensitivity and specificity. There were low to moderate correlations between the cognitive scales and scales for everyday functioning and behaviour. Clinical implications: Our findings allow an objective interpretation of scores on the ACE-III and the M-ACE relative to the MMSE, which may be helpful for clinical services and research trials.

Item Type:	Article
Additional Information:	Supplementary material: Supplementary material is available online at https://doi.org/10.1192/bjb.2023.27. Data availability: Data are available from the corresponding author, L.M., on reasonable request.
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Social Sciences > Research Groups > Cognition, Action and Perception Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Groups > Mental Health
Depositing User:	LivePure Connector
Date Deposited:	14 Jun 2023 15:34
Last Modified:	14 Jun 2023 15:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/92395
DOI:	10.1192/bjb.2023.27

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