The effect of calcium supplementation on calcium and bone metabolism during load carriage in women: Protocol for a randomised controlled crossover trial

Coombs, Charlotte V., Wardle, Sophie L., Shroff, Rukshana, Eisenhauer, Anton, Tang, Jonathan C. Y. ORCID:, Fraser, William D., Greeves, Julie P. and O'Leary, Thomas J. (2023) The effect of calcium supplementation on calcium and bone metabolism during load carriage in women: Protocol for a randomised controlled crossover trial. BMC Musculoskeletal Disorders, 24. ISSN 1471-2474

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Background: Military field exercises are characterised by high volumes of exercise and prolonged periods of load carriage. Exercise can decrease circulating serum calcium and increase parathyroid hormone and bone resorption. These disturbances to calcium and bone metabolism can be attenuated with calcium supplementation immediately before exercise. This randomised crossover trial will investigate the effect of calcium supplementation on calcium and bone metabolism, and bone mineral balance, during load carriage exercise in women. Methods: Thirty women (eumenorrheic or using the combined oral contraceptive pill, intrauterine system, or intrauterine device) will complete two experimental testing sessions either with, or without, a calcium supplement (1000 mg). Each experimental testing session will involve one 120 minute session of load carriage exercise carrying 20 kg. Venous blood samples will be taken and analysed for biochemical markers of bone resorption and formation, calcium metabolism, and endocrine function. Urine will be collected pre- and post-load carriage to measure calcium isotopes for the calculation of bone calcium balance. Discussion: The results from this study will help identify whether supplementing women with calcium during load carriage is protective of bone and calcium homeostasis.

Item Type: Article
Additional Information: Ethics approval and consent to participate: This study has received favourable ethical opinion from the Ministry of Defence Research Ethics Committee (MoDREC); protocol number 1021/MoDREC/19. Informed consent will be obtained from all volunteers by the investigators. All methods carried out in this study will be conducted in accordance with the relevant guidelines and regulations. Study sponsor: British Army, Army Headquarters, Andover, UK. The study sponsor had no role in the study design, data collection, data analysis and interpretation, or writing of the report.
Uncontrolled Keywords: bone metabolism,calcium,exercise,load carriage,supplement,rheumatology,orthopedics and sports medicine ,/dk/atira/pure/subjectarea/asjc/2700/2745
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
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Depositing User: LivePure Connector
Date Deposited: 06 Jun 2023 15:30
Last Modified: 03 Jul 2023 08:30
DOI: 10.1186/s12891-023-06600-w

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