Bilayer-coating strategy for hydrophobic nanoparticles providing colloidal stability, functionality, and surface protection in biological media

Schroter, Alexandra, Arnau del Valle, Carla, Marín, María J. ORCID: https://orcid.org/0000-0001-8021-5498 and Hirsch, Thomas (2023) Bilayer-coating strategy for hydrophobic nanoparticles providing colloidal stability, functionality, and surface protection in biological media. Angewandte Chemie-International Edition, 62 (36). ISSN 1433-7851

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Abstract

The surface chemistry of nanoparticles is a key step on the pathway from particle design towards applications in biologically relevant environments. Here, a bilayer-based strategy for the surface modification of hydrophobic nanoparticles is introduced that leads to excellent colloidal stability in aqueous environments and good protection against disintegration, while permitting surface functionalization via simple carbodiimide chemistry. We have demonstrated the excellent potential of this strategy using upconversion nanoparticles (UCNPs), initially coated with oleate and therefore dispersible only in organic solvents. The hydrophobic oleate capping is maintained and a bilayer is formed upon addition of excess oleate. The bilayer approach renders protection towards luminescence loss by water quenching, while the incorporation of additional molecules containing amino functions yields colloidal stability and facilitates the introduction of functionality. The biological relevance of the approach was confirmed with the use of two model dyes, a photosensitizer and a nitric oxide (NO) probe that, when attached to the surface of the UCNPs, retained their functionality to produce singlet oxygen and detect intracellular NO, respectively. We present a simple and fast strategy to protect and functionalize inorganic nanoparticles in biological media, which is important for controlled surface engineering of nanosized materials for theranostic applications.

Item Type: Article
Additional Information: Funding information: CAV and MJM would like to thank the Royal Society of Chemistry for financial support (Research Enablement Grant E21-2055114014)
Uncontrolled Keywords: 4* ,/dk/atira/pure/researchoutput/REFrank/4_
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Centre for Photonics and Quantum Science
Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Faculty of Science > Research Groups > Chemistry of Light and Energy
Faculty of Science > Research Groups > Chemistry of Life Processes
Depositing User: LivePure Connector
Date Deposited: 05 Jun 2023 16:30
Last Modified: 30 Mar 2024 11:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/92293
DOI: 10.1002/anie.202305165

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