Alcohol consumption and measures of sarcopenic muscle risk: cross-sectional and prospective associations within the UK Biobank Study

Skinner, Jane, Shepstone, Lee, Hickson, Mary and Welch, Ailsa (2023) Alcohol consumption and measures of sarcopenic muscle risk: cross-sectional and prospective associations within the UK Biobank Study. Calcified Tissue International, 113 (2). pp. 143-156. ISSN 0171-967X

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Abstract

Introduction: Alcohol intake is a major modifiable risk factor for many diseases. Alcohol can also damage skeletal muscle health during aging which in turn increases risk of sarcopenia, frailty and falls but this relationship is understudied. The aim of this study was to model the relationship between a full range of alcohol consumption and components of sarcopenic risk, skeletal muscle mass and function, in middle-aged and younger older-aged men and women. Study design: A cross-sectional analyses was undertaken of 196,561 white participants from the UK Biobank with longitudinal analysis also in 12,298 of these participants, with outcome measures for the latter repeated after around four years. For the cross-sectional analysis fractional polynomial curves were fitted in models of measures of skeletal muscle mass, appendicular lean mass/body mass index (ALM/BMI), fat-free mass as a percentage of body weight (FFM%) and grip strength, all predicted from alcohol consumption with models fitted for men and women separately. Alcohol consumption at baseline was based on the mean of up to five dietary recalls, typically over 16 months. Linear regression was used for longitudinal analyses to model the effects of alcohol consumption groups on these measures. All models were adjusted for covariates. Results: In the cross-sectional analysis, modelled values of the muscle mass measures all showed a peak at medium levels of alcohol consumption and a steep decline with increasing alcohol consumption. Modelled differences in muscle mass from zero consumption of alcohol to 160g/d ranged from 3.6% and 4.9% for ALM/BMI for men and women respectively, and 3.6% and 6.1% for FFM%. Grip strength consistently increased with alcohol consumption. No association between alcohol consumption and muscle measures were seen in the longitudinal results. Conclusion: Our results suggest that higher levels of alcohol consumption could have detrimental effects on muscle mass in middle and older aged men and women.

Item Type: Article
Uncontrolled Keywords: alcohol,cross-sectional analysis,muscle mass,muscle strength,sarcopenia,endocrinology, diabetes and metabolism,orthopedics and sports medicine,endocrinology ,/dk/atira/pure/subjectarea/asjc/2700/2712
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care
Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Faculty of Medicine and Health Sciences > Research Centres > Population Health
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Depositing User: LivePure Connector
Date Deposited: 17 Apr 2023 10:30
Last Modified: 26 Oct 2023 02:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/91792
DOI: 10.1007/s00223-023-01081-4

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