Recent developments in molecular sensor designs for inorganic pyrophosphate detection and biological imaging

Anbu, Sellamuthu ORCID:, Paul, Anup, Stasiuk, Graeme J. and Pombeiro, Armando J. L. (2021) Recent developments in molecular sensor designs for inorganic pyrophosphate detection and biological imaging. Coordination Chemistry Review, 431.

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Inorganic pyrophosphate (PPi) is a key anion which plays a crucial role in an extensive range of biological and ecological processes. PPi is involved in many physiological reactions, including nucleic acid replication, chromosomal elongation, cell growth, energy storage and transduction, iron delivery, etc. It is the main causative factor for many bone joints diseases (e.g. pseudogout) and eutrophication related ecological issues. In recent years, PPi is conceived as one of the biological markers for various diseases, including cancer and infectious diseases and an essential target in diverse fields including ecological research. The quantification of PPi levels in live cells can offer critical information on metabolic processes, including DNA replication and tumour progression. Thus, development of new chemosensors for PPi opens up the opportunities to identify novel and promising diagnostic reagents for the genetic diseases and the monitoring of intracellular processes. A repertoire of colourimetric and fluorescent chemosensors for PPi has been developed yet, and many of them were not arrayed and explained in such a way to make the readers understand them comparatively. Therefore, in this critical review, we focused onthe design and function of some unsung chemosensors including metal-free, metal-based, sequential sensors, etc. for PPi detection via diverse binding mechanisms reported from 2010 to the end of the year 2019.

Item Type: Article
Additional Information: Funding Information: S.A. gratefully acknowledges the Fundação para a Ciência e Tecnologia (FCT), Portugal, for the award of postdoctoral fellowship (Ref.: SFRH/BPD/76451/2011) and the RSC Research Fund grant (RF19-7464). A.P. is thankful to the FCT and IST, Portugal, for financial support through FCT “DL/57/2017” (Contracts no. IST-ID/197/2019). GJS would like to thank the MRC for funding (MR/T002573/1). This work was also partially supported by the FCT, through project UIDB/00100/2020 of Centro de Química Estrutural.
Uncontrolled Keywords: anion sensors,pyrophosphate,pyrophosphate imaging,pyrosequencing,sequential sensors,materials chemistry,inorganic chemistry,physical and theoretical chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2500/2505
Faculty \ School: Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 14 Mar 2023 12:30
Last Modified: 14 Jun 2023 14:13
DOI: 10.1016/j.ccr.2020.213744

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