Anhedonia and sensitivity to punishment in schizophrenia, depression and opiate use disorder

Ossola, Paolo, Garrett, Neil ORCID: https://orcid.org/0000-0003-1440-472X, Biso, Letizia, Bishara, Anthony and Marchesi, Carlo (2023) Anhedonia and sensitivity to punishment in schizophrenia, depression and opiate use disorder. Journal of Affective Disorders, 330. pp. 319-328. ISSN 0165-0327

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Abstract

Background: From a behavioural perspective anhedonia is defined as diminished interest in the engagement of pleasurable activities. Despite its presence across a range of psychiatric disorders, the cognitive processes that give rise to anhedonia remain unclear. Methods: Here we examine whether anhedonia is associated with learning from positive and negative outcomes in patients diagnosed with major depression, schizophrenia and opiate use disorder alongside a healthy control group. Responses in the Wisconsin Card Sorting Test – a task associated with healthy prefrontal cortex function – were fitted to the Attentional Learning Model (ALM) which separates learning from positive and negative feedback. Results: Learning from punishment, but not from reward, was negatively associated with anhedonia beyond other socio-demographic, cognitive and clinical variables. This impairment in punishment sensitivity was also associated with faster responses following negative feedback, independently of the degree of surprise. Limitations: Future studies should test the longitudinal association between punishment sensitivity and anhedonia also in other clinical populations controlling for the effect of specific medications. Conclusions: Together the results reveal that anhedonic subjects, because of their negative expectations, are less sensitive to negative feedbacks; this might lead them to persist in actions leading to negative outcomes.

Item Type:	Article
Additional Information:	Author statement: Neil Garrett is funded by a Sir Henry Wellcome Fellowship (209108/Z/17/Z).
Uncontrolled Keywords:	anhedonia,computational psychiatry,learning,punishment,reward,clinical psychology,psychiatry and mental health ,/dk/atira/pure/subjectarea/asjc/3200/3203
Faculty \ School:	Faculty of Social Sciences > School of Psychology
UEA Research Groups:	Faculty of Social Sciences > Research Groups > Social Cognition Research Group Faculty of Social Sciences > Research Groups > Cognition, Action and Perception
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	07 Mar 2023 16:30
Last Modified:	15 Sep 2023 08:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/91424
DOI:	10.1016/j.jad.2023.02.120

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