Ossola, Paolo, Garrett, Neil ORCID: https://orcid.org/0000-0003-1440-472X, Biso, Letizia, Bishara, Anthony and Marchesi, Carlo
(2023)
Anhedonia and sensitivity to punishment in schizophrenia, depression and opiate use disorder.
Journal of Affective Disorders, 330.
pp. 319-328.
ISSN 0165-0327
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Abstract
Background: From a behavioural perspective anhedonia is defined as diminished interest in the engagement of pleasurable activities. Despite its presence across a range of psychiatric disorders, the cognitive processes that give rise to anhedonia remain unclear. Methods: Here we examine whether anhedonia is associated with learning from positive and negative outcomes in patients diagnosed with major depression, schizophrenia and opiate use disorder alongside a healthy control group. Responses in the Wisconsin Card Sorting Test – a task associated with healthy prefrontal cortex function – were fitted to the Attentional Learning Model (ALM) which separates learning from positive and negative feedback. Results: Learning from punishment, but not from reward, was negatively associated with anhedonia beyond other socio-demographic, cognitive and clinical variables. This impairment in punishment sensitivity was also associated with faster responses following negative feedback, independently of the degree of surprise. Limitations: Future studies should test the longitudinal association between punishment sensitivity and anhedonia also in other clinical populations controlling for the effect of specific medications. Conclusions: Together the results reveal that anhedonic subjects, because of their negative expectations, are less sensitive to negative feedbacks; this might lead them to persist in actions leading to negative outcomes.
Item Type: | Article |
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Additional Information: | Author statement: Neil Garrett is funded by a Sir Henry Wellcome Fellowship (209108/Z/17/Z). |
Faculty \ School: | Faculty of Social Sciences > School of Psychology |
Depositing User: | LivePure Connector |
Date Deposited: | 07 Mar 2023 16:30 |
Last Modified: | 22 Mar 2023 10:30 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/91424 |
DOI: | 10.1016/j.jad.2023.02.120 |
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