Protein targeting by the bacterial twin-arginine translocation (Tat) pathway

Berks, Ben C., Palmer, Tracy and Sargent, Frank (2005) Protein targeting by the bacterial twin-arginine translocation (Tat) pathway. Current Opinion in Microbiology, 8 (2). pp. 174-181. ISSN 1369-5274

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The Tat (twin-arginine translocation) protein export system is found in the cytoplasmic membrane of most prokaryotes and is dedicated to the transport of folded proteins. The Tat system is now known to be essential for many bacterial processes including energy metabolism, cell wall biosynthesis, the nitrogen-fixing symbiosis and bacterial pathogenesis. Recent studies demonstrate that substrate-specific accessory proteins prevent improperly assembled substrates from interacting with the Tat transporter. During the transport cycle itself substrate proteins bind to a receptor complex in the membrane which then recruits a protein-translocating channel to carry out the transport reaction.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: LivePure Connector
Date Deposited: 01 Mar 2023 12:31
Last Modified: 01 Mar 2023 12:31
DOI: 10.1016/j.mib.2005.02.010

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