A single-pot template reaction towards a manganese-based T1 contrast agent

Anbu, Sellamuthu ORCID: https://orcid.org/0000-0002-7176-330X, Hoffmann, Sabrina H. L., Carniato, Fabio, Kenning, Lawrence, Price, Thomas W., Prior, Timothy J., Botta, Mauro, Martins, Andre F. and Stasiuk, Graeme J. (2021) A single-pot template reaction towards a manganese-based T1 contrast agent. Angewandte Chemie International Edition, 60 (19). pp. 10736-10744. ISSN 1433-7851

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Abstract

Manganese-based contrast agents (MnCAs) have emerged as suitable alternatives to gadolinium-based contrast agents (GdCAs). However, due to their kinetic lability and laborious synthetic procedures, only a few MnCAs have found clinical MRI application. In this work, we have employed a highly innovative single-pot template synthetic strategy to develop a MnCA, MnL Me, and studied the most important physicochemical properties in vitro. MnL Me displays optimized r 1 relaxivities at both medium (20 and 64 MHz) and high magnetic fields (300 and 400 MHz) and an enhanced r 1 b=21.1 mM −1 s −1 (20 MHz, 298 K, pH 7.4) upon binding to BSA (K a=4.2×10 3 M −1). In vivo studies show that MnL Me is cleared intact into the bladder through renal excretion and has a prolonged blood half-life compared to the commercial GdCA Magnevist. MnL Me shows great promise as a novel MRI contrast agent.

Item Type: Article
Additional Information: Research Funding: Medical Research Council. Grant Number: MR/T002573/1; Royal Society of Chemistry. Grant Number: RF19-7464; Deutsche Forschungsgemeinschaft. Grant Number: EXC 2180 - 390900677
Uncontrolled Keywords: mn-based contrast agents,bishydrated mnca,blood pool agents,in vivo mri,template synthesis,catalysis,chemistry(all) ,/dk/atira/pure/subjectarea/asjc/1500/1503
Faculty \ School: Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 24 Feb 2023 17:30
Last Modified: 30 Jan 2024 03:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/91268
DOI: 10.1002/anie.202100885

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