Interplay of the long axis of the hippocampus and ventromedial prefrontal cortex in schema‐related memory retrieval

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Guo, Dingrong and Yang, Jiongjiong (2020) Interplay of the long axis of the hippocampus and ventromedial prefrontal cortex in schema‐related memory retrieval. Hippocampus, 30 (3). pp. 263-277. ISSN 1050-9631

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Abstract

When new information is relevant to prior knowledge or schema, it can be learned and remembered better. Rodent studies have suggested that the hippocampus and ventromedial prefrontal cortex (vmPFC) are important for processing schema-related information. However, there are inconsistent findings from human studies on the involvement of the hippocampus and its interaction with the vmPFC in schema-related memory retrieval. To address these issues, we used a human analog of the rodent spatial schema task to compare brain activity during immediate retrieval of paired associations (PAs) in schema-consistent and schema-inconsistent conditions. The results showed that the anterior hippocampus was more involved in retrieving PAs in the schema-consistent condition than in the schema-inconsistent condition. Connectivity analyses showed that the anterior hippocampus had stronger coupling with the vmPFC when the participants retrieved newly learned PAs successfully in the schema-consistent (vs. schema-inconsistent) condition, whereas the coupling of the posterior hippocampus with the vmPFC showed the opposite. Taken together, the results shed light on how the long axis of the hippocampus and vmPFC interact to serve memory retrieval via different networks that differ by schema condition.

Item Type:	Article
Additional Information:	Funding Information: The work was supported by a grant from the National Natural Science Foundation of China (31571114, J. Yang).
Uncontrolled Keywords:	anterior hippocampus,memory retrieval,posterior hippocampus,schema,vmpfc,cognitive neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2805
Faculty \ School:	Faculty of Social Sciences > School of Psychology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	03 Feb 2023 14:30
Last Modified:	03 Feb 2023 14:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/90958
DOI:	10.1002/hipo.23154

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