Dietary isothiocyanates: Novel insights into the potential for cancer prevention and therapy

Na, Guanqiong, He, Canxia, Zhang, Shunxi, Tian, Sicong, Bao, Yongping ORCID: and Shan, Yujuan (2023) Dietary isothiocyanates: Novel insights into the potential for cancer prevention and therapy. International Journal of Molecular Sciences, 24 (3). ISSN 1661-6596

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Diet plays an important role in health. A high intake of plant chemicals such as glucosinolates/isothiocyanates can promote optimal health and decrease the risk of cancer. Recent research has discovered more novel mechanisms of action for the effects of isothiocyanates including the modulation of tumor microenvironment, the inhibition of the self-renewal of stem cells, the rearrangement of multiple pathways of energy metabolism, the modulation of microbiota, and protection against Helicobacter pylori. However, the hormetic/biphasic effects of isothiocyanates may make the recommendations complicated. Isothiocyanates possess potent anti-cancer activities based on up-to-date evidence from in vitro and in vivo studies. The nature of hormesis suggests that the benefits or risks of isothiocyanates largely depend on the dose and endpoint of interest. Isothiocyanates are a promising class of cancer-preventative phytochemicals, but researchers should be aware of the potential adverse (and hormetic) effects. In the authors’ opinion, dietary isothiocyanates are better used as adjunctive treatments in combination with known anti-cancer drugs. The application of nano-formulations and the delivery of isothiocyanates are also discussed in this review.

Item Type: Article
Additional Information: Funding information: This study was supported by grants from NSFC [grant number 82073540], and the Cancer Prevention Research Trust UK.
Uncontrolled Keywords: : isothiocyanates,sulforaphane,cancer,angiogenesis,tumor microenvironment,microbiota,stem cells,isothiocyanates,rearrangement of energy metabolism,tumor microenvironment,molecular biology,spectroscopy,catalysis,inorganic chemistry,computer science applications,physical and theoretical chemistry,organic chemistry,sdg 3 - good health and well-being,3* ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 23 Jan 2023 15:31
Last Modified: 13 Nov 2023 17:54
DOI: 10.3390/ijms24031962


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