Aging and the UPR(ER)

Taylor, Rebecca C. ORCID: (2016) Aging and the UPR(ER). Brain Research, 1648 (Part B). pp. 588-593. ISSN 1872-6240

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The aging process is characterized by tissue decline and the onset of age-associated disease. It is not, however, immutable, and aging can be modulated by various genetic and environmental means. One of the interventions that can modulate lifespan is the activation of cellular stress responses, including the unfolded protein response in the endoplasmic reticulum (UPRER). The ability to activate the UPRER declines with age, while its constitutive activation can extend longevity. It also plays complex roles in the onset and progression of many age-related diseases. Understanding how the UPRER changes with age, and how this impacts upon disease development, may open new therapeutic avenues for the treatment of a range of age-associated diseases.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 16 Jan 2023 17:32
Last Modified: 27 Mar 2024 17:31
DOI: 10.1016/j.brainres.2016.04.017

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