Cell Non-autonomous UPRER Signaling

Imanikia, S, Sheng, M and Taylor, RC ORCID: https://orcid.org/0000-0003-3429-3123 (2018) Cell Non-autonomous UPRER Signaling. In: Coordinating Organismal Physiology Through the Unfolded Protein Response. Current topics in microbiology and immunology . Springer. ISBN 978-3-319-78530-1

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The UPRER is an important regulator of secretory pathway homeostasis, and plays roles in many physiological processes. Its broad range of targets and ability to modulate secretion and membrane trafficking make it perfectly positioned to influence intercellular communication, enabling the UPRER to coordinate physiological processes between cells and tissues. Recent evidence suggests that the activation of the UPRER can itself be communicated between cells. This cell non-autonomous route to UPRER activation occurs in multiple species, and enables organism-wide responses to stress that involve processes as diverse as immunity, metabolism, aging and reproduction. It may also play roles in disease progression, making the pathways that mediate cell non-autonomous UPRER signaling a potential source of novel future therapeutics.

Item Type: Book Section
Faculty \ School: Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 16 Jan 2023 17:30
Last Modified: 16 Jan 2023 17:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/90597
DOI: 10.1007/82_2017_38

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