Controlled annealing in adaptive multicomponent gels

Ravarino, Paolo, Panja, Santanu, Bianco, Simona, Koev, Todor, Wallace, Matthew ORCID: https://orcid.org/0000-0002-5751-1827 and Adams, Dave John (2023) Controlled annealing in adaptive multicomponent gels. Angewandte Chemie International Edition, 62 (4). ISSN 1433-7851

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Abstract

We use a pH-driven annealing process to convert between co-assembled and self-sorted networks in multicomponent gels. The initially formed gels at low pH are co-assembled, with the two components coexisting within the same self-assembled structures. We use an enzymatic approach to increase the pH, resulting in a gel-to-sol transition, followed by a hydrolysis to lower the pH once again. As the pH decreases, a self-sorted network is formed by a two-stage gelation process determined by the pKa of each component. This approach can be expanded to layered systems to generate many varied systems by changing composition and rates of pH change, adapting their microstructure and so allowing access to a far greater range of morphologies and complexity than can be achieved in single component systems.

Item Type: Article
Additional Information: Funding Information: PR thanks the University of Bologna for Marco Polo funding. SB and SP thank the University of Glasgow for funding. We thank Bart Dietrich for the synthesis of the FmocFF used here. This work was supported by a UKRI Future Leaders Fellowship to MW (MR/T044020/1). We are grateful for the use of the University of East Anglia (UEA) Faculty of Science NMR facility/.
Uncontrolled Keywords: annealing,co-assembly,multicomponent hydrogel,rheology,catalysis,chemistry(all) ,/dk/atira/pure/subjectarea/asjc/1500/1503
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 15 Dec 2022 04:07
Last Modified: 25 Jan 2023 09:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/90153
DOI: 10.1002/anie.202215813

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