UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases

Warwick, Alasdair N., Curran, Katie, Stuart, Kelsey, Khawaja, Anthony P., Foster, Paul J., Lotery, Andrew J., Quinn, Michael, Madhusudhan, Savita, Balaskas, Konstantinos and Peto, Tunde and UKBB Eye and Vision Consortium (2023) UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases. Eye, 37 (10). 2109–2116. ISSN 0950-222X

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Background/objectives: This study aims to describe the grading methods and baseline characteristics for UK Biobank (UKBB) participants who underwent retinal imaging in 2009–2010, and to characterise individuals with retinal features suggestive of age-related macular degeneration (AMD), glaucoma and retinopathy. Methods: Non-mydriatic colour fundus photographs and macular optical coherence tomography (OCT) scans were manually graded by Central Administrative Research Facility certified graders and quality assured by clinicians of the Network of Ophthalmic Reading Centres UK. Captured retinal features included those associated with AMD (≥1 drusen, pigmentary changes, geographic atrophy or exudative AMD; either imaging modality), glaucoma (≥0.7 cup-disc ratio, ≥0.2 cup-disc ratio difference between eyes, other abnormal disc features; photographs only) and retinopathy (characteristic features of diabetic retinopathy with or without microaneurysms; either imaging modality). Suspected cases of these conditions were characterised with reference to diagnostic records, physical and biochemical measurements. Results: Among 68,514 UKBB participants who underwent retinal imaging, the mean age was 57.3 years (standard deviation 8.2), 45.7% were men and 90.6% were of White ethnicity. A total of 64,367 participants had gradable colour fundus photographs and 68,281 had gradable OCT scans in at least one eye. Retinal features suggestive of AMD and glaucoma were identified in 15,176 and 2184 participants, of whom 125 (0.8%) and 188 (8.6%), respectively, had a recorded diagnosis. Of 264 participants identified to have retinopathy with microaneurysms, 251 (95.1%) had either diabetes or hypertension. Conclusions: This dataset represents a valuable addition to what is currently available in UKBB, providing important insights to both ocular and systemic health.

Item Type: Article
Additional Information: Funding information: The UK Biobank Eye and Vision Consortium is supported by grants from Moorfields Eye Charity, The NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, the Alcon Research Institute and the International Glaucoma Association (UK). ANW is supported by the Wellcome Trust (220558/Z/20/Z). KS is in receipt of a University College London Overseas Research Scholarship and is supported by grants from Fight for Sight (London) (1956A) and The Desmond Foundation. Fight for Sight (London) – ref: 1507 and 1508. Moorfields Eye Charity (Previous Moorfields Special Trustees ref: ST 15 11 E). The Macular Society (London). PJF is supported by an unrestricted grant from The Desmond Foundation. APK is supported by a UK Research and Innovation Future Leaders Fellowship, an Alcon Research Institute Young Investigator Award and a Lister Institute of Preventive Medicine Fellowship.
Uncontrolled Keywords: sensory systems,ophthalmology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2800/2809
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Centres > Population Health
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Depositing User: LivePure Connector
Date Deposited: 15 Dec 2022 04:02
Last Modified: 19 Oct 2023 03:29
DOI: 10.1038/s41433-022-02298-7

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