2022 American College of Rheumatology/EULAR Classification Criteria for Takayasu Arteritis

Grayson, Peter C., Ponte, Cristina, Suppiah, Ravi, Robson, Joanna C., Gribbons, Katherine Bates, Judge, Andrew, Craven, Anthea, Khalid, Sara, Hutchings, Andrew, Danda, Debashish, Luqmani, Raashid A., Watts, Richard A. and Merkel, Peter A. and DCVAS Study Group (2022) 2022 American College of Rheumatology/EULAR Classification Criteria for Takayasu Arteritis. Arthritis & Rheumatology, 74 (12). pp. 1872-1880. ISSN 2326-5191

[thumbnail of Arthritis Rheumatology - 2022 - Grayson - 2022 American College of Rheumatology EULAR Classification Criteria for] PDF (Arthritis Rheumatology - 2022 - Grayson - 2022 American College of Rheumatology EULAR Classification Criteria for) - Accepted Version
Restricted to Repository staff only until 8 November 2023.

Request a copy

Abstract

Objective: To develop and validate new classification criteria for Takayasu arteritis (TAK). Methods: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 6 phases: 1) identification of candidate criteria items, 2) collection of candidate items present at diagnosis, 3) expert panel review of cases, 4) data-driven reduction of candidate items, 5) derivation of a points-based classification score in a development data set, and 6) validation in an independent data set. Results: The development data set consisted of 316 cases of TAK and 323 comparators. The validation data set consisted of an additional 146 cases of TAK and 127 comparators. Age ≤60 years at diagnosis and imaging evidence of large-vessel vasculitis were absolute requirements to classify a patient as having TAK. The final criteria items and weights were as follows: female sex (+1), angina (+2), limb claudication (+2), arterial bruit (+2), reduced upper extremity pulse (+2), reduced pulse or tenderness of a carotid artery (+2), blood pressure difference between arms of ≥20 mm Hg (+1), number of affected arterial territories (+1 to +3), paired artery involvement (+1), and abdominal aorta plus renal or mesenteric involvement (+3). A patient could be classified as having TAK with a cumulative score of ≥5 points. When these criteria were tested in the validation data set, the model area under the curve was 0.97 (95% confidence interval [95% CI] 0.94–0.99) with a sensitivity of 93.8% (95% CI 88.6–97.1%) and specificity of 99.2% (95% CI 96.7–100.0%). Conclusion: The 2022 American College of Rheumatology/EULAR classification criteria for TAK are now validated for use in research.

Item Type: Article
Additional Information: Funding Information: The Diagnostic and Classification Criteria in Vasculitis (DCVAS) study, which included the development of this classification criteria, was funded by grants from the American College of Rheumatology (ACR), EULAR, the Vasculitis Foundation, and the University of Pennsylvania Vasculitis Center. This study was also supported by the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH.
Uncontrolled Keywords: immunology and allergy,rheumatology,immunology ,/dk/atira/pure/subjectarea/asjc/2700/2723
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 15 Dec 2022 03:59
Last Modified: 16 Dec 2022 09:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/90113
DOI: 10.1002/art.42324

Actions (login required)

View Item View Item