Increased phage resistance through lysogenic conversion accompanying emergence of monophasic Salmonella Typhimurium ST34 pandemic strain

Charity, Oliver J., Acton, Luke, Bawn, Matt, Tassinari, Eleonora, Thilliez, Gaёtan, Chattaway, Marie A., Dallman, Timothy J., Petrovska, Liljana and Kingsley, Robert A. ORCID: (2022) Increased phage resistance through lysogenic conversion accompanying emergence of monophasic Salmonella Typhimurium ST34 pandemic strain. Microbial Genomics, 8 (11). ISSN 2057-5858

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Salmonella enterica serovar Typhimurium (S. Typhimurium) comprises a group of closely related human and animal pathogens that account for a large proportion of all Salmonella infections globally. The epidemiological record of S. Typhimurium in Europe is characterized by successive waves of dominant clones, each prevailing for approximately 10–15 years before replacement. Succession of epidemic clones may represent a moving target for interventions aimed at controlling the spread and impact of this pathogen on human and animal health. Here, we investigate the relationship of phage sensitivity and population structure of S. Typhimurium using data from the Anderson phage typing scheme. We observed greater resistance to phage predation of epidemic clones circulating in livestock over the past decades compared to variants with a restricted host range implicating increased resistance to phage in the emergence of epidemic clones of particular importance to human health. Emergence of monophasic S. Typhimurium ST34, the most recent dominant multidrug-resistant clone, was accompanied by increased resistance to phage predation during clonal expansion, in part by the acquisition of the mTmII prophage that may have contributed to the fitness of the strains that replaced ancestors lacking this prophage.

Item Type: Article
Additional Information: Funding Information: RK was supported by research grants BB/N007964/1 and BB/M025489/1, and by the UKRI Institute Strategic Programme Microbes in the Food Chain BB/R012504/1 and its constituent project(s) BBS/E/F/000PR10348 and BBS/E/F/000PR10349. OC was supported by a BBSRC DTP studentship (BB/ M011216/1). MAC was supported in this study and received funding from the National Institute for Health Research (NIHR) Health Protection Research Unit in Genomics and Enabling Data (NIHR200892). The views expressed are those of the authors and not necessarily those of the NIHR, the Department of Health or UKHSA.
Uncontrolled Keywords: epidemiology,evolution,genomics,monophasic,phage,salmonella,genetics,molecular biology,epidemiology,microbiology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1311
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 15 Dec 2022 03:53
Last Modified: 09 Mar 2024 01:46
DOI: 10.1099/mgen.0.000897


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