Virus factories and mini-organelles generated for virus replication

Wileman, Tom, Netherton, Chris and Powell, Penny ORCID: (2023) Virus factories and mini-organelles generated for virus replication. In: Encyclopedia of Cell Biology (Second Edition). Elsevier, pp. 423-435. ISBN 978-0-12-821624-8

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Many viruses replicate and assemble in subcellular microenvironments called virus factories or “viroplasm”. Virus factories increase the efficiency of replication and at the same time protect viruses from antiviral defenses. We describe how viruses reorganize cellular membrane compartments and cytoskeleton to generate these “mini-organelles” and how these rearrangements parallel cellular responses to stress such as protein aggregation and DNA damage.

Item Type: Book Section
Additional Information: Publisher Copyright: © 2016 Elsevier Inc. All rights reserved.
Uncontrolled Keywords: aggresome,autophagosome,autophagy,double membrane vesicle,pml-nb,replicase,spherule,viroplasm,virus factory,virus replication,medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 15 Dec 2022 01:02
Last Modified: 27 Feb 2023 10:32
DOI: 10.1016/B978-0-12-821618-7.00041-9

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