Exploring the potential of cycloidal computed tomography for advancing intraoperative specimen imaging

Morgó, Oriol Roche i, Massimi, Lorenzo, Suaris, Tamara, Endrizzi, Marco, Munro, Peter R. T., Savvidis, Savvas, Havariyoun, Glafkos, Hawker, P. M. Sam, Astolfo, Alberto, Larkin, Oliver J., Nelan, Rachel L., Jones, J. Louise, Pelt, Daniël M., Bate, David, Olivo, Alessandro and Hagen, Charlotte K. (2021) Exploring the potential of cycloidal computed tomography for advancing intraoperative specimen imaging. In: Proceedings Volume 11840: Developments in X-Ray Tomography XIII. Proceedings of SPIE - The International Society for Optical Engineering, 11840 . SPIE, USA. ISBN 9781510645189

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A preliminary investigation into the use of cycloidal computed tomography for intraoperative specimen imaging is presented. Intraoperative imaging is applied in time-sensitive clinical settings, where obtaining a high-resolution, highquality image within minutes is paramount in evaluating the success of operations and/or the need for additional surgery. As a flexible imaging method that is compatible with x-ray phase contrast imaging, cycloidal computed tomography can provide both high spatial resolution and high image contrast, whilst keeping scan times short thanks to an effective under-sampling approach. To gather early evidence, the method was tested on resected breast and oesophageal tissue. The results, although preliminary, indicate that cycloidal imaging may indeed be beneficial for intraoperative specimen imaging, although further studies are required to confirm this potential.

Item Type: Book Section
Additional Information: Funding Information: This work is supported by the Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) (203145/Z/16/Z). Additional funding by the Wellcome Trust [200137/Z/15/Z] and by EPSRC [EP/T005408/1] is acknowledged. C. K. Hagen is supported by the Royal Academy of Engineering, under the Research Fellowship scheme. A. Olivo is supported by the Royal Academy of Engineering, under the Chair in Emerging Technologies scheme. P. R. T. Munro is funded by the Royal Society under the University Research Fellowships scheme. S. Savvidis was supported by the EPSRC-funded UCL Centre for Doctoral Training in Medical Imaging (EP/L016478/1). D. M. Pelt is supported by The Netherlands Organisation for Scientific Research (NWO), project number 016.Veni.192.235. The authors wish to acknowledge the roles of the Breast Cancer Now Tissue Bank in collecting and making available the samples, and the patients who have generously donated the tissues which have been utilised in the generation of this publication. Publisher Copyright: © 2021 SPIE.
Uncontrolled Keywords: cycloidal computed tomography,edge illumination,intraoperative specimen imaging,micro computed tomography,phase contrast,spatial resolution,structured illumination,x-ray imaging,electronic, optical and magnetic materials,condensed matter physics,computer science applications,applied mathematics,electrical and electronic engineering ,/dk/atira/pure/subjectarea/asjc/2500/2504
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UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 15 Dec 2022 01:02
Last Modified: 06 Jun 2024 14:34
URI: https://ueaeprints.uea.ac.uk/id/eprint/90009
DOI: 10.1117/12.2594547

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