Cognitive impairment in the immune-mediated inflammatory diseases compared with age-matched controls: systematic review and meta-regression

Gwinnutt, James M., Toyoda, Task, Barraclough, Michelle, Verstappen, Suzanne M. M., Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788 and Macgregor, Alexander ORCID: https://orcid.org/0000-0003-2163-2325 (2022) Cognitive impairment in the immune-mediated inflammatory diseases compared with age-matched controls: systematic review and meta-regression. Seminars in Arthritis and Rheumatism. ISSN 0049-0172

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Abstract

Objectives: To compare the magnitude of cognitive impairment against age-expected levels across the immune mediated inflammatory diseases (IMIDs: systemic lupus erythematosus [SLE], rheumatoid arthritis [RA], axial spondyloarthritis [axSpA], psoriatic arthritis [PsA], psoriasis [PsO]). Methods: A pre-defined search strategy was implemented in Medline, Embase and Psychinfo on 29/05/2021. Inclusion criteria were: (i) observational studies of an IMID, (ii) healthy control comparison, (iii) measuring cognitive ability (overall, memory, complex attention/executive function, language/verbal fluency), and (iv) sufficient data for meta-analysis. Standardised mean differences (SMD) in cognitive assessments between IMIDs and controls were pooled using random-effects meta-analysis. IMIDs were compared using meta-regression. Results: In total, 65 IMID groups were included (SLE: 39, RA: 19, axSpA: 1, PsA: 2 PsO: 4), comprising 3141 people with IMIDs and 9333 controls. People with IMIDs had impairments in overall cognition (SMD: -0.57 [95% CI -0.70, -0.43]), complex attention/executive function (SMD -0.57 [95% CI -0.69, -0.44]), memory (SMD -0.55 [95% CI -0.68, -0.43]) and language/verbal fluency (SMD -0.51 [95% CI -0.68, -0.34]). People with RA and people with SLE had similar magnitudes of cognitive impairment in relation to age-expected levels. People with neuropsychiatric SLE had larger impairment in overall cognition compared with RA. Conclusions: People with IMIDs have moderate impairments across a range of cognitive domains. People with RA and SLE have similar magnitudes of impairment against their respective age-expected levels, calling for greater recognition of cognitive impairment in both conditions. To further understand cognition in the IMIDs, more large-scale, longitudinal studies are needed.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 18 Nov 2022 14:30
Last Modified: 18 Nov 2022 14:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/89936
DOI: 10.1016/j.semarthrit.2022.152131

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