The effects of collagen peptides on exercise-induced gastro-intestinal stress: a randomized, controlled trial

Taylor, Guy, Leonard, Amber, Tang, Jonathan C. Y. ORCID: https://orcid.org/0000-0001-6305-6333, Dunn, Rachel, Fraser, William D., Virgilio, Nicolina, Prawitt, Janne, Stevenson, Emma and Clifford, Tom (2022) The effects of collagen peptides on exercise-induced gastro-intestinal stress: a randomized, controlled trial. European Journal of Nutrition. ISSN 1436-6207

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Abstract

Purpose: We examined the effects of collagen peptides (CP) supplementation on exercise induced-gastro-intestinal (GI) stress. Methods: In a randomized, crossover design, 20 volunteers (16 males: V ̇O2max, 53.4±5.9 ml·kg-1) completed 3 trials: a non-exercise rest trial, with no supplement (REST) and then an exercise trial with CP (10 g·day-1) or placebo control (CON) supplements, which were consumed for 7 days prior to, and 45 min before, a 70 min run at 70-90% of V ̇O2max. Outcome measures included urinary lactulose and rhamnose (L/R), intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), anti-LPS antibody, monocyte chemoattractant protein-1 (MCP-1), interleukin (IL) 6 and 8, cortisol, alkaline phosphatase (ALP) (measured pre, 10 min post and 2 h post) and subjective GI symptoms. Results: There were no differences in heart rate, perceived exertion, thermal comfort, or core temperature during exercise in the CP and CON trials (all P>0.05). I-FABP was higher in CP (2538±1221pg/ml) and CON (2541±766pg/ml) vs. REST 2 h post (1893±1941pg/ml) (both P<0.05). LPS increased in CON vs. REST 2 h post (+71.8pg/ml; P < 0.05). Anti-LPS antibody decreased in CON and CP vs. REST at post (both P<0.05). There were no differences in MCP-1, IL-6, and IL-8 between the CP and CON trials (all P>0.05), and no differences in L/R or GI symptoms between CON and CP (all P>0.05). Conclusion: Collagen peptides did not modify exercise-induced changes in inflammation, GI integrity or subjective GI symptoms but LPS was higher in CON 2 h post-exercise and thus future studies may be warranted.

Item Type: Article
Additional Information: Funding: Funding for the study was provided by Rousselot BV.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 16 Nov 2022 10:30
Last Modified: 16 Nov 2022 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/89881
DOI: 10.1007/s00394-022-03051-2

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