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Spencer, Arthur P. C., Lequin, Maarten H., de Vries, Linda S., Brooks, Jonathan C. W. 
ORCID: https://orcid.org/0000-0003-3335-6209, Jary, Sally, Tonks, James, Cowan, Frances M., Thoresen, Marianne and Chakkarapani, Ela
(2023)
Mammillary body abnormalities and cognitive outcomes in children cooled for neonatal encephalopathy.
Developmental Medicine and Child Neurology, 65 (6).
pp. 792-802.
ISSN 0012-1622
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Abstract
Aim: To evaluate mammillary body abnormalities in school-age children without cerebral palsy treated with therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy (cases) and matched controls, and associations with cognitive outcome, hippocampal volume, and diffusivity in the mammillothalamic tract (MTT) and fornix. Method: Mammillary body abnormalities were scored from T1-weighted magnetic resonance imaging (MRI) in 32 cases and 35 controls (median age [interquartile range] 7 years [6 years 7 months-7 years 7 months] and 7 years 4 months [6 years 7 months-7 years 7 months] respectively). Cognition was assessed using the Wechsler Intelligence Scale for Children, Fourth Edition. Hippocampal volume (normalized by total brain volume) was measured from T1-weighted MRI. Radial diffusivity and fractional anisotropy were measured in the MTT and fornix, from diffusion-weighted MRI using deterministic tractography. Results: More cases than controls had mammillary body abnormalities (34% vs 0%; p < 0.001). Cases with abnormal mammillary bodies had lower processing speed (p = 0.016) and full-scale IQ (p = 0.028) than cases without abnormal mammillary bodies, and lower scores than controls in all cognitive domains (p < 0.05). Cases with abnormal mammillary bodies had smaller hippocampi (left p = 0.016; right p = 0.004) and increased radial diffusivity in the right MTT (p = 0.004) compared with cases without mammillary body abnormalities. Interpretation: Cooled children with mammillary body abnormalities at school-age have reduced cognitive scores, smaller hippocampi, and altered MTT microstructure compared with those without mammillary body abnormalities, and matched controls.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding information: Baily Thomas Charitable Fund. Grant Number: TRUST/VC/AC/SG4681-7596; David Telling Charitable Trust; Medical Research Council. Grant Number: MR/N026969/1; Sparks. Grant Numbers: 05/BTL/01, 14/BTL/01; The Moulton Foundation; Wellcome Trust. Grant Number: WT220070/Z/20/Z. |
| Uncontrolled Keywords: | diffusion mri,images,bodies |
| Faculty \ School: | Faculty of Social Sciences > School of Psychology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 14 Nov 2022 11:30 |
| Last Modified: | 09 May 2023 14:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/89839 |
| DOI: | 10.1111/dmcn.15453 |
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