Metabolic syndrome, atrial fibrillation, and stroke:Tackling an emerging epidemic

Hajhosseiny, Reza, Matthews, Gareth K. ORCID: and Lip, Gregory Y.H. (2015) Metabolic syndrome, atrial fibrillation, and stroke:Tackling an emerging epidemic. Heart Rhythm, 12 (11). pp. 2332-2343. ISSN 1547-5271

Full text not available from this repository. (Request a copy)


The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle. These essentially modifiable risk factors are becoming more prevalent with the widespread adoption of so-called Western lifestyles. This review examines the physiology underlying the link between the metabolic syndrome and AF. Next, it highlights the importance of addressing lifestyle-related risk factors to mitigate the trend toward increasing AF prevalence. It then goes on to discuss the importance of stroke prevention therapy in patients with established AF, focusing on the relative merits of various available options for anticoagulation. Given the recent availability of comprehensive data on the 4 currently available non-vitamin K antagonist oral anticoagulant drugs, this review concludes by discussing the relative merits of specific agents in individual patient groups.

Item Type: Article
Additional Information: Publisher Copyright: © 2015 Heart Rhythm Society.
Uncontrolled Keywords: anticoagulation,atrial fibrillation,metabolic syndrome,noacs,stroke,warfarin,cardiology and cardiovascular medicine,physiology (medical),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2705
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 10 Nov 2022 13:30
Last Modified: 14 Nov 2022 00:51
DOI: 10.1016/j.hrthm.2015.06.038

Actions (login required)

View Item View Item