Defining Cell Identity with Single-Cell Omics

Mincarelli, Laura, Lister, Ashleigh, Lipscombe, James and Macaulay, Iain C. (2018) Defining Cell Identity with Single-Cell Omics. Proteomics, 18 (18). ISSN 1615-9853

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Cells are a fundamental unit of life, and the ability to study the phenotypes and behaviors of individual cells is crucial to understanding the workings of complex biological systems. Cell phenotypes (epigenomic, transcriptomic, proteomic, and metabolomic) exhibit dramatic heterogeneity between and within the different cell types and states underlying cellular functional diversity. Cell genotypes can also display heterogeneity throughout an organism, in the form of somatic genetic variation—most notably in the emergence and evolution of tumors. Recent technical advances in single-cell isolation and the development of omics approaches sensitive enough to reveal these aspects of cell identity have enabled a revolution in the study of multicellular systems. In this review, we discuss the technologies available to resolve the genomes, epigenomes, transcriptomes, proteomes, and metabolomes of single cells from a wide variety of living systems.

Item Type: Article
Additional Information: Publisher Copyright: © 2018 The Authors. Proteomics Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Uncontrolled Keywords: epigenomics,genomics,proteomics,single-cell,technology,transcriptomics,biochemistry,molecular biology ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School: Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 01 Nov 2022 16:30
Last Modified: 01 Nov 2022 16:30
DOI: 10.1002/pmic.201700312

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