Loss of REEP4 causes paralysis of the Xenopus embryo

Argasinska, Joanna, Rana, Amer A. ORCID: https://orcid.org/0000-0002-2330-4643, Gilchrist, Michael J., Lachani, Kim, Young, Alice and Smith, James C. (2009) Loss of REEP4 causes paralysis of the Xenopus embryo. International Journal of Developmental Biology, 53 (1). pp. 37-43. ISSN 0214-6282

Full text not available from this repository. (Request a copy)


Members of the REEP (Receptor expression enhancing protein) family contain a TB2/DP1, HVA22 domain that is involved in intracellular trafficking and secretion. Consistent with the presence of this domain, REEP1 and REEP3 enhance the expression of odorant and taste receptors in mammals, while mutation of these genes causes defects in neural development. REEP4 was identified in the course of a functional antisense morpholino oligonucleotide screen searching for genes involved in the early development of Xenopus tropicalis: although over-expression of the gene causes no phenotype, embryos lacking REEP4 develop a slightly kinked body axis and are paralysed. At tailbud stages of development, REEP4 is expressed in the somites and neural tube. The paralysis observed in embryos lacking REEP4 might therefore be caused by defects in the nervous system or in muscle. To address this point, we examined the expression of various neural and muscle markers and found that although all are expressed normally at early stages of development, many are down regulated by the tailbud stage. This suggests that REEP4 plays a role in the maintenance of both the nervous system and the musculature.

Item Type: Article
Uncontrolled Keywords: muscle,neural,reep4,xenopus,embryology,developmental biology ,/dk/atira/pure/subjectarea/asjc/2700/2710
Faculty \ School: Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 01 Nov 2022 14:32
Last Modified: 01 Nov 2022 14:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/89473
DOI: 10.1387/ijdb.072542ja

Actions (login required)

View Item View Item