Applications of nuclear reprogramming and directed differentiation in vascular regenerative medicine

Rana, Amer A. ORCID: and Callery, Elizabeth M. (2015) Applications of nuclear reprogramming and directed differentiation in vascular regenerative medicine. New Biotechnology, 32 (1). pp. 191-198. ISSN 1871-6784

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As vertebrates proceed through embryonic development the growing organism cannot survive on diffusion of oxygen and nutrients alone and establishment of vascular system is fundamental for embryonic development to proceed. Dysfunction of the vascular system in adults is at the heart of many disease states such as hypertension and atherosclerosis. In this review we will focus on attempts to generate the key cells of the vascular system, the endothelial and smooth muscle cells, using human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs). Regardless of their origin, be it embryonic or via somatic cell reprogramming, pluripotent stem cells provide limitlessly self-renewing populations of material suitable for the generation of multi-lineage isogenic vascular cells-types that can be used as tools to study normal cell and tissue biology, model disease states and also as tools for drug screening and future cell therapies.

Item Type: Article
Additional Information: Funding Information: The work was funded by British Heart Foundation and British Heart Foundation Centre for Regenerative Medicine , Fight for Sight , Robert McApline Foundation and Dinosaur Trust and supported by the Foundation Le Ducq and Cambridge NIHR Biomedical Research Centre . Publisher Copyright: © 2014.
Uncontrolled Keywords: biotechnology,bioengineering,molecular biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1305
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 01 Nov 2022 14:31
Last Modified: 07 Nov 2022 00:49
DOI: 10.1016/j.nbt.2014.07.005

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