Microbiome-based interventions to modulate gut ecology and the immune system

Hitch, Thomas C. A., Hall, Lindsay J. ORCID: https://orcid.org/0000-0001-8938-5709, Walsh, Sarah Kate, Leventhal, Gabriel E., Slack, Emma, de Wouters, Tomas, Walter, Jens and Clavel, Thomas (2022) Microbiome-based interventions to modulate gut ecology and the immune system. Mucosal Immunology, 15 (6). 1095–1113. ISSN 1933-0219

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The gut microbiome lies at the intersection between the environment and the host, with the ability to modify host responses to disease-relevant exposures and stimuli. This is evident in how enteric microbes interact with the immune system, e.g., supporting immune maturation in early life, affecting drug efficacy via modulation of immune responses, or influencing development of immune cell populations and their mediators. Many factors modulate gut ecosystem dynamics during daily life and we are just beginning to realise the therapeutic and prophylactic potential of microbiome-based interventions. These approaches vary in application, goal, and mechanisms of action. Some modify the entire community, such as nutritional approaches or faecal microbiota transplantation, while others, such as phage therapy, probiotics, and prebiotics, target specific taxa or strains. In this review, we assessed the experimental evidence for microbiome-based interventions, with a particular focus on their clinical relevance, ecological effects, and modulation of the immune system.

Item Type: Article
Additional Information: Funding Information: Open Access funding enabled and organized by Projekt DEAL. T.C.A.H. and T.C. received funding from the DFG (German Research Foundation): project-ID 403224013 (SFB 1382).
Uncontrolled Keywords: immunology and allergy,immunology ,/dk/atira/pure/subjectarea/asjc/2700/2723
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 24 Oct 2022 11:30
Last Modified: 01 Aug 2023 11:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/89300
DOI: 10.1038/s41385-022-00564-1


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